Donor specific antibodies median fluorescence intensity levels are the best indicator for monitoring desensitization treatment in kidney transplant.
نویسندگان
چکیده
Vol. 11 | No. 03 | May June 2014 | UROLOGY JOURNAL Donor Specific Antibodies Median Fluorescence Intensity Levels Are the Best Indicator for Monitoring Desensitization Treatment in Kidney Transplant Francisco Boix,1 Santiago Llorente,2 Anna Mrowiec,1 Jorge Eguia,1 Ruth López-Hernández,1 Maria Victoria Bernardo,1 María Rosa Moya-Quiles,1,3 José A. Campillo,1,3 Alfredo Minguela,1,3 Luisa Jimeno,2 María R. ÁlvarezLópez,1,3 Manuel Muro1,3
منابع مشابه
Increased C4d in post-reperfusion biopsies and increased donor specific antibodies at one-week post transplant are risk factors for acute rejection in mild to moderately sensitized kidney transplant recipients
In order to define the intensity of immunosuppression, we examined risk factors for acute rejection in desensitization protocols that use baseline donor-specific antibody levels measured as mean fluorescence intensity (MFImax). The study included 146 patients transplanted with a negative flow crossmatch and a mean follow-up of 18 months with the majority (83%) followed for at least 1 year. At t...
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BACKGROUND Desensitization with IVIG and rituximab allows acceptable graft survival in sensitized kidney transplant recipients with preexisting donor-specific antibodies (DSAs) and a positive crossmatch. There is little published data reporting the durability of DSA removal in kidney transplant recipients treated with IVIG and rituximab. METHODS We conducted a 3-year prospective DSA monitorin...
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Background: Cyclosporine is the main immunosuppressive agent used in organ transplantation which leads to considerable improvement in graft survival. The large inter- and intra- patient variability in cyclosporine pharmacokinetics coupled with the agent’s narrow therapeutic index and adverse effects necessitate therapeutic monitoring of cyclosporine blood levels. Objective: The aim of this stu...
متن کاملClinical Significance of Pretransplant Donor-Specific Antibodies in the Setting of Negative Cell-Based Flow Cytometry Crossmatching in Kidney Transplant Recipients.
Antibodies to donor-specific HLA antigens (donor-specific antibodies [DSA]) detected by single-antigen bead (SAB) analysis prior to kidney transplant have been associated with inferior graft outcomes. However, studies of pretransplant DSA, specifically in the setting of a negative flow cytometry crossmatch (FCXM) without desensitization therapy, are limited. Six hundred and sixty kidney and kid...
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عنوان ژورنال:
- Urology journal
دوره 11 3 شماره
صفحات -
تاریخ انتشار 2014